pentobarbital will lower the extent or result of artemether/lumefantrine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. Coadministration with powerful CYP3A4 inducers can lead to reduced serum concentrations and loss of antimalarial efficacy
pentobarbital will minimize the level or outcome of estrogens esterified by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
pentobarbital will lower the level or effect of clarithromycin by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Small/Significance Unidentified.
Reserve concomitant prescribing of those drugs in sufferers for whom other treatment method selections are insufficient. Restrict dosages and durations on the least expected. Watch carefully for signs of respiratory melancholy and sedation.
pentobarbital will reduce the level or impact of isradipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Small/Significance Not known.
pentobarbital decreases levels of panobinostat by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Sturdy CYP3A4 inducers can reduce panobinostat concentrations by ~70% and bring about treatment method failure.
pentobarbital will lessen the level or influence of voriconazole by affecting hepatic enzyme CYP2C9/ten metabolism. Slight/Significance Not known.
Reserve concomitant prescribing of such drugs in individuals for whom other treatment selections are inadequate. Limit dosages and durations into the minimum expected. Keep track of carefully for indications of respiratory depression and sedation.
pentobarbital will reduce the extent or result of cannabidiol by more info impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep track of Intently. Take into account an increase in cannabidiol dosage (based upon clinical reaction and tolerability) when coadministered with a powerful CYP3A4 inducer.
pentobarbital will reduce the extent or result of diazepam buccal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch. Potent or reasonable CYP3A4 inducers may possibly boost price of diazepam elimination; hence, efficacy of diazepam might be reduced.
pentobarbital will reduce the level or outcome of atazanavir by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Significance Unknown.
pentobarbital will lessen the level or result of buspirone by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.
Coadministration of zuranolone with other CNS depressants may perhaps boost impairment of psychomotor performance or CNS depressant effects. If unavoidable, look at dose reduction. .
pentobarbital will lower the level or result of zaleplon by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unidentified.